Factors predicting response and graft-versus-host disease after donor lymphocyte infusions: a study on 593 infusions
نویسندگان
چکیده
منابع مشابه
Prognostic factors for acute graft-versus-host disease after donor lymphocyte infusions.
In a recent report of the fatal course of a rituximab-treated patient, we have demonstrated that tumor cell agglutination (TCA) might be a key mechanism of rituximab-induced adverse reactions. The pattern of intravascular leukostasis shown by histopathologic examinations was clearly different from findings in other patients with high leukocyte counts.1 Dr Muttuswamy Sivakumaran reports an inter...
متن کاملHost T cells resist graft-versus-host disease mediated by donor leukocyte infusions.
Delayed lymphocyte infusions (DLIs) are used to treat relapse occurring post bone marrow transplantation (BMT) and to increase the donor chimerism in recipients receiving nonmyeloablative conditioning. As compared with donor lymphocytes given early post-BMT, DLIs are associated with a reduced risk of graft-vs-host disease (GVHD). The mechanism(s) responsible for such resistance have remained in...
متن کاملThe association of CD25 expression on donor CD8+ and CD4+ T cells with graft-versus-host disease after donor lymphocyte infusions.
BACKGROUND AND OBJECTIVES Graft-versus-host disease (GvHD) remains a major complication of allogeneic stem cell transplantation (SCT) and donor lymphocyte infusions (DLI). CD25-expressing donor T cells may be involved in the prevention or induction of GvHD as these cells comprise both CD4 +CD25+ regulatory T (Treg) cells and preactivated CD4+ or CD8+ conventional T cells. Therefore, we evaluate...
متن کاملThe occurrence of graft-versus-host disease is the major predictive factor for response to donor lymphocyte infusions in multiple myeloma.
The graft-versus-myeloma (GVM) effect of donor lymphocyte infusions (DLIs) is well established. We now report the outcome of DLI in 54 patients with relapsed myeloma following allogeneic transplantation. Twenty-eight patients (52%) responded, 19 patients (35%) with a partial response and 9 patients (17%) with a complete response. Progression-free and overall survival were 19 and 23 months, resp...
متن کاملHepatitic variant of graft-versus-host disease after donor lymphocyte infusion.
Graft-versus-host disease (GVHD) of the liver is characterized by bile duct damage and portal lymphocytic infiltrate. We report acute hepatitislike presentation of GVHD after donor lymphocyte infusion (DLI). Between April 1998 and September 2001, 73 patients received 94 DLI treatments. Liver GVHD developed after DLI in 22 (30%) patients whose median age was 43 years (range, 21 to 61 years). Ons...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2003
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1703883